
Broad Spectrum Monthly Cat Parasite Protection
Product Description
NexGard COMBO Topical for Cats 1.8–5.5 lbs is a monthly veterinary parasite protection formulated for cats and kittens 8 weeks and older. This easy-to-apply topical solution protects against fleas, ticks, heartworm disease, and treats common internal parasites including roundworms, hookworms, and tapeworms, all in one dose. It offers one-and-done monthly coverage to keep your cat healthy year-round.
Benefits
- Broad Parasite Protection: Covers fleas, ticks, heartworm disease, and major intestinal worms with one monthly application.
- Easy Monthly Use: Simple topical applicator makes giving your cat protection fast and stress-free.
- Kills Before Eggs: Works quickly to kill adult fleas before they can lay eggs.
- Vet Trusted Formula: Combines three proven active ingredients for effective parasite control.
- Safe for Kittens: Approved for cats as young as 8 weeks and 1.8 lbs.
- Year-Round Protection: Monthly use helps ensure constant parasite defense in every season.

Variants
1.8–5.5 lbs (Purple Box)
5.6–16.5 lbs (Yellow Box)
Ingredients
Composition Table
Ingredient |
Quantity per mL |
Esafoxolaner |
12 mg |
Eprinomectin |
4 mg |
Praziquantel |
83 mg |
Other Ingredients: dimethyl isosorbide, unstabilized glycerol formal, butylated hydroxytoluene.
How to Use
Recommended-Dosage Chart
Cat Weight |
Applicator Volume |
Approved Use |
1.8–5.5 lbs |
0.3 mL |
Monthly topical parasite protection |
Dosage & Administration Instructions
- Prescription Status: This product is labeled for use only by or on the order of a licensed veterinarian.
- Monthly Labeling: NexGard COMBO is approved for once monthly topical application according to manufacturer labeling.
- Weight Specific Use: The 0.3 mL applicator is labeled for cats weighing 1.8 to 5.5 pounds.
- Veterinary Oversight: Treatment decisions and continued use should be determined by a licensed veterinarian.
Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.
Additional Information
Precautions
- Neurologic History: Isoxazoline products have been associated with neurologic reactions, including seizures, in some cats.
- Topical Use Only: The product is labeled strictly for topical application and not for oral administration.
- Breeding Safety: Safety has not been evaluated in breeding, pregnant, or lactating cats.
- Age Limitation: NexGard COMBO is not labeled for kittens under 8 weeks of age.
Possible Side Effects
- Gastrointestinal Signs: Vomiting and reduced appetite were among the most commonly reported adverse reactions.
- Application Reactions: Temporary hair changes or redness may occur at the application site.
- Lethargy Episodes: Some cats showed temporary lethargy during post-treatment observation periods.
- Hypersalivation Risk: Excessive salivation may occur if the product is accidentally ingested.
Storage Information
- Temperature Range: Store between 59°F and 86°F, with brief excursions up to 104°F permitted.
- Light Protection: The product should be kept protected from direct light until use.
- Original Packaging: Applicators should remain in original packaging prior to administration.
Shipping & Return
We offer ground, express, priority, and international delivery; see our shipping policy for details.
For return instructions or product concerns, please refer to our detailed refund policy.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Frequently Asked Questions
Q1: What parasites does NexGard COMBO protect cats against?
Ans:NexGard COMBO is labeled to protect cats against fleas, ticks, heartworm disease, roundworms, hookworms, and tapeworms with monthly topical use. It is the first topical feline product approved to also kill tapeworms, offering broad spectrum parasite coverage.
Q2: Is NexGard COMBO safe for kittens?
Ans: According to manufacturer labeling, NexGard COMBO is approved for kittens 8 weeks of age and older that weigh at least 1.8 pounds. Safety and effectiveness have not been evaluated in kittens younger than this labeled minimum age or weight.
Q3: How often is NexGard COMBO labeled to be used?
Ans: NexGard COMBO is approved by the manufacturer for once monthly topical use in cats. For heartworm prevention, monthly use is labeled year round or during periods of mosquito exposure, based on veterinary guidance and regional parasite risk.
Q4: Does NexGard COMBO require a prescription?
Ans: Yes, NexGard COMBO is a prescription veterinary medication. Federal law restricts its use to order by or on the supervision of a licensed veterinarian, ensuring appropriate parasite prevention decisions are made based on individual pet health needs.
Q5: What side effects have been reported with NexGard COMBO?
Ans: Manufacturer safety studies report the most common adverse reactions as vomiting, application site reactions, decreased appetite, and lethargy. Neurologic reactions have been reported rarely with isoxazoline class products, including in cats without prior neurologic history.
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1. Order Processing Time
Order Cut-Off Time: Orders placed on business days before 6:00 PM local business time are considered received on the same day.
Orders placed after 6:00 PM, on weekends, or on public holidays will be processed on the next business day.
Processing Time: Orders are typically processed and prepared for shipment within 1–5 business days after the order is received.
Processing time includes order verification, quality checks, and packaging.
Processing time does not include shipping or delivery time.
2. Shipping Methods and Delivery Time
We currently offer the following shipping methods at checkout:
Priority Shipping: $5.99
Expected delivery time: 1–2 business days
Standard Shipping: $2.99
Expected delivery time: 3–6 business days
Free Shipping: $0
Expected delivery time: 5–8 business days
Delivery times are estimated from the time the order has been shipped and may vary depending on the shipping destination, carrier operations, weather conditions, holidays, or other unforeseen delays.
Estimated delivery times are provided for reference only and are not guaranteed.
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We work with reliable third-party shipping carriers to deliver your orders safely and efficiently. Carrier selection is determined based on destination, package size, and service availability.
Carrier delays are outside of our control, and we are not responsible for delays caused by the carrier.
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We ship orders to addresses within the United States.
Shipping costs are displayed at checkout based on the shipping method selected by the customer.
Available shipping options may include Priority Shipping, Standard Shipping, and Free Shipping.
No additional standard shipping fees will be charged beyond the shipping cost shown at checkout.
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Please allow up to 48 hours for tracking details to become active.
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We are not responsible for delays caused by incorrect or incomplete address information, or for packages that are lost or undeliverable due to address errors.
Additional shipping or handling fees may apply for re-delivery.
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If your order has not arrived within the estimated delivery timeframe, please contact our customer support team.
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While we strive to help resolve shipping issues, we are not responsible for delays or losses caused by third-party carriers.
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If your package arrives damaged, please contact us within a reasonable time after delivery and provide clear photos of the damaged packaging and items.
We will review the case and assist according to our Return & Refund Policy.
9. Policy Updates
We reserve the right to modify or update this Shipping Policy at any time.
Changes will be effective immediately upon posting on this page.
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If you have any questions regarding this Shipping Policy or your order status, please contact us using the contact information provided in the footer.
Thank you for shopping with us. This Return & Refund Policy explains the terms and conditions under which returns and refunds are accepted for purchases made through our website. By placing an order, you agree to the terms outlined below.
1. No Exchange Policy
We do not offer exchanges at this time.
This policy allows us to maintain efficient inventory management, faster order processing, and consistent product availability for all customers. If you would like a different item, size, color, or version, please return the original item (if eligible) and place a new order separately.
2. Return Eligibility
You may request a return if all of the following conditions are met:
The return request is submitted within 30 days of confirmed delivery
The item is unused, unwashed, and in its original condition
The item includes all original packaging, tags, accessories, and documentation
The item is not listed as non-returnable (see Section 3)
Returns requested after the 30-day period will not be accepted.
3. Non-Returnable Items
The following items are not eligible for return:
Items marked as Final Sale or Non-Returnable at the time of purchase
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Digital products or downloadable content
Items that show signs of use, damage, or alteration not caused by us
4. How to Initiate a Return
To start a return, please contact our customer support team and provide:
Your order number
The item(s) you wish to return
Reason for return (for internal reference only)
Returns sent without prior authorization may be refused.
5. Return Shipping
Customers are responsible for return shipping costs unless the return is due to a defective or incorrect item.
We recommend using a trackable shipping method, as we are not responsible for lost or damaged return shipments.
Original shipping fees are non-refundable, except where required by law.
6. Refunds
Once we receive and inspect your returned item, we will notify you of the approval or rejection of your refund.
If approved:
Refunds will be issued to the original payment method
Processing typically takes 1–3 business days, depending on your payment provider
Refund amounts may be reduced for items returned in unacceptable condition
7. Damaged or Incorrect Items
If you receive an item that is damaged, defective, or incorrect, please contact us within a reasonable time after delivery and provide clear photos of the issue. We will review the case and, if approved, issue a refund in accordance with this policy.
8. Refused or Undeliverable Shipments
Orders that are refused or returned due to incorrect shipping information may be subject to additional handling or shipping fees, which may be deducted from the refund amount.
9. Policy Updates
We reserve the right to update or modify this Return & Refund Policy at any time. Changes will be effective immediately upon posting on this page.
10. Contact Us
If you have any questions regarding this Return & Refund Policy or need assistance with a return, please contact us using the contact information provided in the footer.
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